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|Title:||Interaction of magnetic nanoparticles with U87MG cells studied by synchrotron radiation X-ray fluorescence techniques|
|Authors:||GIANONCELLI Alessandra; MARMORATO Patrick; PONTI Jessica; PASCOLO Lorella; KAULICH Burkhard; UBOLDI CHIARA; ROSSI Francois; MAKOVEC Darko; KISKINOVA Maya; CECCONE Giacomo|
|Citation:||X-RAY SPECTROMETRY vol. 42 no. 4 p. 316–320|
|Type:||Articles in periodicals and books|
|Abstract:||Synchrotron radiation (SR) X-ray microscopy (XRM) combined with X-ray fluorescence (XRF) microspectroscopy provides unique information that have pushed the frontiers of biological research, particularly when investigating intracellular mechanisms. This work reports a SR-XRF microspectroscopy investigation on the distribution and the potential toxicity of Fe3O4 and CoFe2O4 nanoparticles (NPs) in U87MG glioblastoma-astrocytoma cells. The U87MG cells exposed to NPs concentrations ranging from 5 to 250 μg/mL for 24h were analyzed in order to monitor both morphological and chemical changes. The SR-XRF maps complemented with XRM absorption and phase contrast images have revealed different intracellular distribution patterns for the two nanoparticles types allowing deduce different mechanism of toxicity.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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