Title: Interaction of magnetic nanoparticles with U87MG cells studied by synchrotron radiation X-ray fluorescence techniques
Authors: GIANONCELLI AlessandraMARMORATO PatrickPONTI JessicaPASCOLO LorellaKAULICH BurkhardUBOLDI CHIARAROSSI FrancoisMAKOVEC DarkoKISKINOVA MayaCECCONE Giacomo
Citation: X-RAY SPECTROMETRY vol. 42 no. 4 p. 316–320
Publisher: WILEY-BLACKWELL
Publication Year: 2012
JRC N°: JRC72236
ISSN: 0049-8246
URI: http://onlinelibrary.wiley.com/doi/10.1002/xrs.2475/abstract
http://publications.jrc.ec.europa.eu/repository/handle/JRC72236
DOI: 10.1002/xrs.2475
Type: Articles in periodicals and books
Abstract: Synchrotron radiation (SR) X-ray microscopy (XRM) combined with X-ray fluorescence (XRF) microspectroscopy provides unique information that have pushed the frontiers of biological research, particularly when investigating intracellular mechanisms. This work reports a SR-XRF microspectroscopy investigation on the distribution and the potential toxicity of Fe3O4 and CoFe2O4 nanoparticles (NPs) in U87MG glioblastoma-astrocytoma cells. The U87MG cells exposed to NPs concentrations ranging from 5 to 250 μg/mL for 24h were analyzed in order to monitor both morphological and chemical changes. The SR-XRF maps complemented with XRM absorption and phase contrast images have revealed different intracellular distribution patterns for the two nanoparticles types allowing deduce different mechanism of toxicity.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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