Simple and fast procedure of labelling DOTATATE with 86Y and 44Sc.
Beta+ emitting 44Sc (T1/2 = 3.92 h) and 86Y (T1/2 = 14.87 h) are prospective radionuclides for diagnostic imaging using the PET technique. They can be produced in medical cyclotrons with the (p,n) reaction on enriched 44Ca/86SrCO3 targets and 44Sc additionally from 44Ti/44Sc generators. The main advantages of these radionuclides are the relatively long half-life and the formation of the “matched pair” with therapeutic radioisotopes, 47Sc and 90Y, respectively. A simple and fast procedure is presented for labeling of DOTATATE with 44Sc and 86Y. DOTATATE was used as a model molecule and results can be transferred to labelling of other DOTA-bioconjugates. The proposed method can be applicable for PET imaging, but clinical investigation is necessary.
KRAJEWSKI Seweryn;
CYDZIK Izabel;
ABBAS Kamel;
BULGHERONI Antonio;
SIMONELLI Federica;
HOLZWARTH Uwe;
MAJKOWSKA-PILIP Agnieszka;
BILEWICZ Aleksander;
2013-01-09
SPRINGER
JRC76684
1619-7070,
http://link.springer.com/content/pdf/10.1007%2Fs00259-012-2225-6,
https://publications.jrc.ec.europa.eu/repository/handle/JRC76684,
10.1007/s00259-012-2219-4,
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