Title: Modeling in vitro cell-based assays experiments: Cell population dynamics
Authors: ZALDIVAR COMENGES JOSÉ MWAMBAUGH JOHNJUDSON RICHARD
Citation: DEVELOPMENTS IN ENVIRONMENTAL MODELLING vol. 25 p. 51-72
Publisher: ELSEVIER BV
Publication Year: 2012
JRC N°: JRC77275
ISSN: 0167-8892
URI: https://www.sciencedirect.com/science/article/pii/B9780444593962000043
http://publications.jrc.ec.europa.eu/repository/handle/JRC77275
DOI: 10.1016/B978-0-444-59396-2.00004-3
Type: Articles in periodicals and books
Abstract: We have developed an integrated model that couples a fate model with a cell growth model and a toxic effect model to analyze the dynamics of cell populations when subject to a toxicant in cell-based assays experiments. The model has been used to analyze A549 cytotoxicity assays by simulating the population dynamics and comparing with experimental data. This approach opens a new way of analyzing in vitro experiments and offers the possibility of extrapolating the values obtained to calculate in vivo human toxicology thresholds.
JRC Directorate:Health, Consumers and Reference Materials

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