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|Title:||Modeling in vitro cell-based assays experiments: Cell population dynamics|
|Authors:||ZALDIVAR COMENGES JOSÉ M; WAMBAUGH JOHN; JUDSON RICHARD|
|Citation:||DEVELOPMENTS IN ENVIRONMENTAL MODELLING vol. 25 p. 51-72|
|Type:||Articles in periodicals and books|
|Abstract:||We have developed an integrated model that couples a fate model with a cell growth model and a toxic effect model to analyze the dynamics of cell populations when subject to a toxicant in cell-based assays experiments. The model has been used to analyze A549 cytotoxicity assays by simulating the population dynamics and comparing with experimental data. This approach opens a new way of analyzing in vitro experiments and offers the possibility of extrapolating the values obtained to calculate in vivo human toxicology thresholds.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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