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|Title:||Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles|
|Authors:||WANG G.; DE KRUIJFF R. M.; ROL A; THIJSSEN L.; MENDES E; MORGENSTERN Alfred; BRUCHERTSEIFER Frank; STUART M.c.a.; WOLTERBEEK H.th.; DENKOVA A.g.|
|Citation:||APPLIED RADIATION AND ISOTOPES vol. 85 p. 45-53|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Type:||Articles in periodicals and books|
|Abstract:||Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of 221Fr and 213Bi when encapsulating 225Ac.|
|JRC Directorate:||Nuclear Safety and Security|
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