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dc.contributor.authorBROGGI Francescaen_GB
dc.contributor.authorPONTI Jessicaen_GB
dc.contributor.authorGIUDETTI Guidoen_GB
dc.contributor.authorFRANCHINI Fabioen_GB
dc.contributor.authorStone Vickien_GB
dc.contributor.authorPASCUAL GARCIA CESARen_GB
dc.contributor.authorROSSI Francoisen_GB
dc.date.accessioned2015-05-28T10:02:13Z-
dc.date.available2014-01-15en_GB
dc.date.available2015-05-28T10:02:13Z-
dc.date.created2014-01-09en_GB
dc.date.issued2013en_GB
dc.date.submitted2013-03-06en_GB
dc.identifier.citationBionanomaterials, Special Issue Nanosafety vol. 14 no. 1-2 p. 49-60en_GB
dc.identifier.issn2193-066Xen_GB
dc.identifier.urihttp://www.degruyter.com/view/j/biomat.2013.14.issue-1-2/bnm-2013-0006/bnm-2013-0006.xmlen_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC80504-
dc.description.abstractSilver nanoparticles (Ag NPs) are one of the most common nanomaterials (NM) present in nanotechnology-based products. In this work, the physical chemical properties of Ag NPs suspensions of 44 nm, 84 nm and 100 nm sizes and synthesized in our laboratory were characterized. The NM-300 material (average size of 17 nm), supplied by the Joint Research Centre Nanomaterials Repository was also included in the present study. In addition, their potential cytotoxicity was tested on Balb3T3 cell line by the Colony Forming efficiency, while their carcinogenic potential and genotoxicity were tested by the assessment of morphological transformation induction and micronuclei formation respectively. After 24 h of exposure, NM-300 showed cytotoxicity with an IC50 of 8 µM while for the other NM tested, values of IC50 were higher than 10 µM. After 72 h of exposure, Ag NPs showed size-dependent cytotoxic effect with IC50 values of 1.5 µM (NM-300), 1.7 µM (Ag 44nm), 1.9 µM (Ag 84 nm) and 3.2 µM (Ag 100 nm). None of the Ag NPs tested was able to induce either morphological transformation or micronuclei formation.en_GB
dc.description.sponsorshipJRC.I.4-Nanobiosciencesen_GB
dc.format.mediumOnlineen_GB
dc.languageENGen_GB
dc.publisherDe Gruyteren_GB
dc.relation.ispartofseriesJRC80504en_GB
dc.titleSilver nanoparticles induce cytotoxicity, but not cell transformation or genotoxicity on Balb3T3 mouse fibroblastsen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1515/bnm-2013-0006en_GB
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