Title: DNA double strand break assessment as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor radiotherapy
Authors: GRAF FranziskaFAHRER JörgMAUS StephanMORGENSTERN AlfredBRUCHERTSEIFER FrankVENKATACHALAM S.FOTTNER C.WEBER Matthias M.HUELSENBECK JohannesSCHRECKENBERGER MKAINA BMIEDERER Matthias
Citation: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 40 no. S2 p. S107
Publisher: SPRINGER
Publication Year: 2013
JRC N°: JRC80827
ISSN: 1619-7070
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC80827
DOI: 10.1007/s00259-013-2535-3
Type: Articles in periodicals and books
Abstract: Alpha-particle emitters display high linear energy transfer combined with short range and are promising for treatment of tumor micrometastases. Indeed, efficiency and high specificity of tumor-specific antibodies labeled with alpha emitting nuclides were described in vitro and in vivo. Radiolabeled somatostatin analogues with high affinity to somatostatin receptor overexpressing tumors are an attractive option for peptide-receptor radionuclide therapy of metastasized neuroendocrine tumors and great clinical success has been demonstrated with Lutetium-177 as therapeutic isotope. In this study, we investigated cellular effects of alpha-particle emitter Actinium-225 in comparison to beta-particle emitter Lutetium-177 labeled somatostatin analogue DOTATOC in vitro and in vivo. Cellular studies were performed in p53 dependent and somatostatin receptor expressing rat pancreatic acinar carcinoma AR42J cells.
JRC Directorate:Nuclear Safety and Security

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