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dc.contributor.authorGRAF Franziskaen_GB
dc.contributor.authorFAHRER Jörgen_GB
dc.contributor.authorMAUS Stephanen_GB
dc.contributor.authorMORGENSTERN Alfreden_GB
dc.contributor.authorBRUCHERTSEIFER Franken_GB
dc.contributor.authorVENKATACHALAM S.en_GB
dc.contributor.authorFOTTNER C.en_GB
dc.contributor.authorWEBER Matthias M.en_GB
dc.contributor.authorHUELSENBECK Johannesen_GB
dc.contributor.authorSCHRECKENBERGER Men_GB
dc.contributor.authorKAINA Ben_GB
dc.contributor.authorMIEDERER Matthiasen_GB
dc.date.accessioned2013-12-19T01:01:53Z-
dc.date.available2013-12-18en_GB
dc.date.available2013-12-19T01:01:53Z-
dc.date.created2013-12-06en_GB
dc.date.issued2013en_GB
dc.date.submitted2013-03-21en_GB
dc.identifier.citationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING vol. 40 no. S2 p. S107en_GB
dc.identifier.issn1619-7070en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC80827-
dc.description.abstractAlpha-particle emitters display high linear energy transfer combined with short range and are promising for treatment of tumor micrometastases. Indeed, efficiency and high specificity of tumor-specific antibodies labeled with alpha emitting nuclides were described in vitro and in vivo. Radiolabeled somatostatin analogues with high affinity to somatostatin receptor overexpressing tumors are an attractive option for peptide-receptor radionuclide therapy of metastasized neuroendocrine tumors and great clinical success has been demonstrated with Lutetium-177 as therapeutic isotope. In this study, we investigated cellular effects of alpha-particle emitter Actinium-225 in comparison to beta-particle emitter Lutetium-177 labeled somatostatin analogue DOTATOC in vitro and in vivo. Cellular studies were performed in p53 dependent and somatostatin receptor expressing rat pancreatic acinar carcinoma AR42J cells.en_GB
dc.description.sponsorshipJRC.E.5-Nuclear chemistryen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSPRINGERen_GB
dc.relation.ispartofseriesJRC80827en_GB
dc.titleDNA double strand break assessment as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor radiotherapyen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1007/s00259-013-2535-3en_GB
JRC Directorate:Nuclear Safety and Security

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