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|Title:||225Ac and 213Bi alpha-Particle-Emitter Therapy in Combination with SAHA and 17-AAG|
|Authors:||SENTHAMIZHCHELVAN Srinivasan; SONG H.; MORGENSTERN Alfred; SGOUROS G.|
|Citation:||World Journal of Nuclear Medicine vol. 12 no. Supplement 1 p. 48 (Paper n° O-013)|
|ISSN:||1450-1147 (print), 1607-3312 (online)|
|Type:||Articles in periodicals and books|
|Abstract:||Alpha-particle emitter radiopharmaceutical therapy (alpha-RPT) is a promising approach to cancer therapy. Alpha-particles lead to highly disruptive and largely irreparable deoxy ribonucleic acid (DNA) double strand breaks capable of killing a cell with as few as one to two tracks through the nucleus. Although the ability to repair alpha-induced DNA damage is independent of alpha-dose-rate the efficacy of alphaemitter with a long half-life can be compromised when targeting very rapidly proliferating tumor cells if the dose-rate is outpaced by the proliferation rate. In this study, we investigate alpha-particle emitter radiopharmaceutical therapy (alpha-RPT) using 225Ac (T1/2=10 days) and 213Bi (T1/2=45.6 min) in combination with clinically approved tumor growth suppressor, suberoylanilide hydroxamic acid (SAHA) and cell cycle blocker, 17-(Allylamino)-17-demethoxy- geldanamycin (17-AAG) in breast cancer cells.|
|JRC Directorate:||Nuclear Safety and Security|
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