Retention studies in polymer vesicles of recoiling atoms as a result of alpha decay

Alpha radionuclide therapy has a great potential for cancer treatment as shown by a large number of pre-clinical and clinical studies. In vivo generators capable of delivering a highly efficient cascade of alpha particles are also steadily gaining importance. Currently, 225Ac is the most potential radionuclide that can be used as an in vivo generator, providing four alpha particles with a total energy of 28 MeV. However, the alpha emitting daughter nuclides of 225Ac may deviate from their intended destination due to recoil effects and cause unwanted toxicity to healthy tissue. According to previous simulation studies1 we developed polymer vesicles (polymersomes) to retain recoil atoms subsequent to alpha decay.

WANG G.;  VAN BUEREN J;  MORGENSTERN Alfred;  BRUCHERTSEIFER Frank;  WOLTERBEEK H.Th.;  MENDES E;  DENKOVA A.G.; 

2013-06-21

Oak Ridge National Laboratory

JRC82797