Anti–Prostate-Specific Membrane Antigen Liposomes Loaded with 225Ac for Potential Targeted Antivascular a-Particle Therapy of Cancer

This study evaluates targeted liposomes loaded with the alpha-particle generator Actinium-225 (225Ac) to selectively kill PSMA-expressing cells with the aim to evaluate their potential for targeted antivascular radiotherapy. Our studies demonstrate that anti-PSMA targeted liposomes loaded with 225Ac selectively bind, become internalized and kill PSMA-expressing cells including endothelial cells induced to express PSMA. These findings combined with the unique ability of liposomes to be easily tuned, in terms of size and surface modification, for optimizing biodistributions suggest the potential of PSMA targeting liposomes encapsulating alpha-particle emitters for selective antivascular alpha-radiotherapy.

BANDEKAR Amey;  ZHU Charles;  JINDAL Rohit;  BRUCHERTSEIFER Frank;  MORGENSTERN Alfred;  SOFOU Stavroula; 

2014-03-10

SOC NUCLEAR MEDICINE INC

JRC82799

0161-5505,   

http://jnm.snmjournals.org/content/55/1/107,    https://publications.jrc.ec.europa.eu/repository/handle/JRC82799,   

10.2967/jnumed.113.125476,