Title: Microbicidal Power of Alpha Radiation in Sterilizing Germinating Bacillus anthracis Spores
Authors: RIVERA J.MORGENSTERN AlfredBRUCHERTSEIFER FrankKEARNEY JohnTURNBOUGH CharlesDADACHOVA E.Casadevall Arturo
Citation: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 58 no. 3 p. 1813-1815
Publisher: AMER SOC MICROBIOLOGY
Publication Year: 2014
JRC N°: JRC82866
ISSN: 0066-4804
URI: http://aac.asm.org/content/58/3/1813
http://publications.jrc.ec.europa.eu/repository/handle/JRC82866
DOI: 10.1128/AAC.01266-13
Type: Articles in periodicals and books
Abstract: Radioimmunotherapy (RIT) takes advantage of the specificity and affinity of the antigen21 antibody interaction to deliver microbicidal radioactive nuclides to a site of infection. In this study, we investigated the microbicidal properties of an alpha-emitting 213Bi-labeled mAb, EA2-1, that binds to the immunodominant antigen on Bacillus anthracis spores. Our results showed that dormant spores were highly resistant to 213Bi-EA2-1. Significant spore killing was observed following treatment with 300 μCi labeled 213Bi-EA2-1, however, this effect was not dependent on the mAb. In contrast, when spores were allowed to partially germinate, 213Bi-EA2-1 mediated mAb-specific killing was observed in a dose dependent manner. Dormant spores are very resistant to RIT and germinating spores can be effectively targeted by this treatment.
JRC Directorate:Nuclear Safety and Security

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