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http://publications.jrc.ec.europa.eu/repository/handle/JRC82866| Title: | Microbicidal Power of Alpha Radiation in Sterilizing Germinating Bacillus anthracis Spores |
| Authors: | RIVERA J.; MORGENSTERN Alfred; BRUCHERTSEIFER Frank; KEARNEY John; TURNBOUGH Charles; DADACHOVA E.; Casadevall Arturo |
| Citation: | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 58 no. 3 p. 1813-1815 |
| Publisher: | AMER SOC MICROBIOLOGY |
| Publication Year: | 2014 |
| JRC N°: | JRC82866 |
| ISSN: | 0066-4804 |
| URI: | http://aac.asm.org/content/58/3/1813 http://publications.jrc.ec.europa.eu/repository/handle/JRC82866 |
| DOI: | 10.1128/AAC.01266-13 |
| Type: | Articles in periodicals and books |
| Abstract: | Radioimmunotherapy (RIT) takes advantage of the specificity and affinity of the antigen21 antibody interaction to deliver microbicidal radioactive nuclides to a site of infection. In this study, we investigated the microbicidal properties of an alpha-emitting 213Bi-labeled mAb, EA2-1, that binds to the immunodominant antigen on Bacillus anthracis spores. Our results showed that dormant spores were highly resistant to 213Bi-EA2-1. Significant spore killing was observed following treatment with 300 μCi labeled 213Bi-EA2-1, however, this effect was not dependent on the mAb. In contrast, when spores were allowed to partially germinate, 213Bi-EA2-1 mediated mAb-specific killing was observed in a dose dependent manner. Dormant spores are very resistant to RIT and germinating spores can be effectively targeted by this treatment. |
| JRC Directorate: | Nuclear Safety and Security |
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