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|Title:||Microbicidal Power of Alpha Radiation in Sterilizing Germinating Bacillus anthracis Spores|
|Authors:||RIVERA J.; MORGENSTERN Alfred; BRUCHERTSEIFER Frank; KEARNEY John; TURNBOUGH Charles; DADACHOVA E.; Casadevall Arturo|
|Citation:||ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 58 no. 3 p. 1813-1815|
|Publisher:||AMER SOC MICROBIOLOGY|
|Type:||Articles in periodicals and books|
|Abstract:||Radioimmunotherapy (RIT) takes advantage of the specificity and affinity of the antigen21 antibody interaction to deliver microbicidal radioactive nuclides to a site of infection. In this study, we investigated the microbicidal properties of an alpha-emitting 213Bi-labeled mAb, EA2-1, that binds to the immunodominant antigen on Bacillus anthracis spores. Our results showed that dormant spores were highly resistant to 213Bi-EA2-1. Significant spore killing was observed following treatment with 300 μCi labeled 213Bi-EA2-1, however, this effect was not dependent on the mAb. In contrast, when spores were allowed to partially germinate, 213Bi-EA2-1 mediated mAb-specific killing was observed in a dose dependent manner. Dormant spores are very resistant to RIT and germinating spores can be effectively targeted by this treatment.|
|JRC Directorate:||Nuclear Safety and Security|
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