Adverse outcome pathways: hype or hope?
Toxicity testing typically focuses on generating data concerning the adverse effects of chemical substances on human health or the environment. However, there is an increasing desire to go beyond observation and prioritize the elucidation of the molecular machinery that drives the manifestation of toxicological apical endpoints (Andersen et al., 2012). This view was clearly embodied with the introduction of so-called toxicity pathways, which denote cellular response cascades that, when sufficiently perturbed, are expected to result in an adverse health outcome (NRC, 2007; OECD, 2012a).
VINKEN Mathieu;
WHELAN Maurice;
ROGIERS Vera;
2014-01-10
SPRINGER HEIDELBERG
JRC83526
0340-5761,
http://link.springer.com/article/10.1007%2Fs00204-013-1093-6,
https://publications.jrc.ec.europa.eu/repository/handle/JRC83526,
10.1007/s00204-013-1093-6,
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