Please use this identifier to cite or link to this item:
|Title:||Adverse outcome pathways: hype or hope?|
|Authors:||VINKEN Mathieu; WHELAN Maurice; ROGIERS Vera|
|Citation:||ARCHIVES OF TOXICOLOGY vol. 88 no. 1 p. 1-2|
|Type:||Articles in periodicals and books|
|Abstract:||Toxicity testing typically focuses on generating data concerning the adverse effects of chemical substances on human health or the environment. However, there is an increasing desire to go beyond observation and prioritize the elucidation of the molecular machinery that drives the manifestation of toxicological apical endpoints (Andersen et al., 2012). This view was clearly embodied with the introduction of so-called toxicity pathways, which denote cellular response cascades that, when sufficiently perturbed, are expected to result in an adverse health outcome (NRC, 2007; OECD, 2012a).|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
Files in This Item:
There are no files associated with this item.
Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.