Validation of analytical methods for the WFD “watch list” pilot exercise
Validation of an analytical method is a necessary step in controlling the quality of quantitative analysis. Method validation is an established process which is the provision of documentary evidence that a system fulfills its pre-defined specification or the process of providing that an analytical method is acceptable for its intended purpose.
The objectives of the present study were:
• to validate a SPE-LC-MS/MS method for the determination of carbamazepine (CBZ), 10,11-dihydro-10,11-dihydroxy-carbamazepine (CBZ-DiOH), sulfamethoxazole (SMZ) and pentafluoropropionic acid (PFPrA) in surface water samples;
• to validate a SPE-GC-MS method for the determination of tris (1-chloro-2-propyl) phosphate (TCPP) content in surface water samples.
Method validations were performed according to the ISO 17025 requirement and the BT/TF151 WI CSS 99026 document.
The calibration curves, working ranges, recoveries, detection and quantification limits, trueness as well as repeatability were determined.
The budget uncertainty was also estimated following a top-down approach based on in-house validation data.
TAVAZZI Simona;
SUURKUUSK Gert;
PARACCHINI Bruno;
LOOS Robert;
MARIANI Giulio;
GAWLIK Bernd;
2013-08-30
Publications Office of the European Union
JRC83535
978-92-79-32515-1,
1831-9424,
EUR 26081,
OP LB-NA-26081-EN-N,
https://publications.jrc.ec.europa.eu/repository/handle/JRC83535,
10.2788/93960,
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