Title: Validation of analytical methods for the WFD “watch list” pilot exercise
Publisher: Publications Office of the European Union
Publication Year: 2013
JRC N°: JRC83535
ISBN: 978-92-79-32515-1
ISSN: 1831-9424
Other Identifiers: EUR 26081
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC83535
DOI: 10.2788/93960
Type: EUR - Scientific and Technical Research Reports
Abstract: Validation of an analytical method is a necessary step in controlling the quality of quantitative analysis. Method validation is an established process which is the provision of documentary evidence that a system fulfills its pre-defined specification or the process of providing that an analytical method is acceptable for its intended purpose. The objectives of the present study were: • to validate a SPE-LC-MS/MS method for the determination of carbamazepine (CBZ), 10,11-dihydro-10,11-dihydroxy-carbamazepine (CBZ-DiOH), sulfamethoxazole (SMZ) and pentafluoropropionic acid (PFPrA) in surface water samples; • to validate a SPE-GC-MS method for the determination of tris (1-chloro-2-propyl) phosphate (TCPP) content in surface water samples. Method validations were performed according to the ISO 17025 requirement and the BT/TF151 WI CSS 99026 document. The calibration curves, working ranges, recoveries, detection and quantification limits, trueness as well as repeatability were determined. The budget uncertainty was also estimated following a top-down approach based on in-house validation data.
JRC Directorate:Sustainable Resources

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