Current and emerging in vitro methods for genotoxicity and carcinogenicity

The evaluation of genotoxicity and carcinogenicity is an essential prerequisite for the assessment of pharmaceuticals, industrial chemicals and consumer products potential hazard and for their marketing authorization. A number of well-established in vitro and in vivo testing methods are available and able to predict genotoxic and carcinogenic potential, yet research is on-going and is aimed at the development of a new generation of in vitro tests to enhance their predictivity and performance and to reduce the number of animals. In this context, the following Chapter is meant to review the existing in vitro testing methods and update on the emerging in vitro approaches for the assessment of genotoxicity and carcinogenicity.

MADIA Federica;  PHRAKONKHAM Pascal;  CORVI Raffaella; 

2014-07-15

Humana Press Springer Science + Business Media, LLC

JRC84619

978-1-4939-0520-1,   

1557-2153,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC84619,   

10.1007/978-1-4939-0521-8_14,