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|Title:||Optimisation of an analytical method and results from the inter-laboratory comparison of the migration of regulated substances from food packaging into the new mandatory EU simulant for dry foodstuffs|
|Authors:||JAKUBOWSKA NATALIA; BELDI Giorgia; BACH AURELIE; SIMONEAU Catherine|
|Citation:||FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE& RISK ASSESSMENT|
|Publisher:||TAYLOR & FRANCIS LTD|
|Type:||Articles in periodicals and books|
|Abstract:||This publication presents the outcome of the development, optimisation and validation at EU level of a harmonised method for using poly (2,6-diphenyl phenylene oxide, abbreviated PPPO here) which is stipulated in Regulation (EU) No 10/2011 as food simulant E for testing specific migration from plastics into dry foodstuffs. Two methods for fortifying respectively PPPO and a Low Density Polyethylene (LDPE) film with surrogate substances that are relevant to food contact were developed. A protocol for cleaning the PPPO and an efficient analytical method was developed for the quantification of Butylhydroxytoluene (BHT), Benzophenone (BP), Diisobutylphthalate (DiBP), Diethyladipate (DEHA) and 1,2-cyclohexanedicarboxylic acid, diisononyl (DINCH) from PPPO. A protocol for a migration test from plastics using small migration cells was also developed. The harmonised method was validated by an interlaboratory comparison (ILC) with 16 national reference laboratories for food contact materials in the European Union. This allowed to obtain data on precision and laboratory performance for both migration and quantification for the first time. The results showed that the validation ILC was successful even taking into account the complexity of the exercise. The results showed that the method performance was 7-9% repeatability standard deviation (rsd) for most substances (regardless of concentration), with 12% rsd for the high level of BHT and for DiBP at very low levels. The reproducibility results for the 16 EU laboratories were in the range of 20-30% for the quantification from PPPO (for the 3 levels of concentrations of the 5 substances) and 15-40% from migration experiments from the fortified plastic at 60C for 10 days and subsequent quantification. Considering the lack of the data previously available in the literature, this work demonstrated that the validation of a method is possible both for migration and for quantification.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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