Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action

Summary The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report on “Toxicity Testing in the 21st Century: a Vision and a Strategy.” As part of its activities to further the science of pathway-based approaches to toxicity, the Human Toxicology Project Consortium convened a workshop, “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action.” Goals of the workshop were to inform 1) the process of pathway development, 2) the scope of two liver-specific pathways for liver fibrosis and steatosis developed by the European Commission Joint Research Centre, and 3) ways in which pathway approaches can be used in decision-making processes. Discussions and presentations were directed at assessing the state-of-the-art in pathway development and to build on this experience using the prototype pathways as examples.

WILLETT Catherine;  CAVERLY RAE Jessica;  GOYAK Katy;  MINSAVAGE Gary;  WESTMORELAND Carl;  ANDERSEN Melvin E.;  AVIGAN Mark;  DUCHÉ Daniel;  HARTUNG T.;  JAESCHKE Hartmut;  KLEENSANG Andre;  LANDESMANN Brigitte;  TOOLE Colleen;  ROWAN Andrew;  SCHULTZ Terry;  SEED Jennifer;  SENIOR John;  SHAH Imran;  SUBRAMANIAN Kas;  VINKEN Mathieu;  WATKINS Paul; 

2014-07-31

SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH

JRC85193

1868-596X,   

http://www.altex.ch/resources/WR_Willett_140217.pdf,    https://publications.jrc.ec.europa.eu/repository/handle/JRC85193,   

10.14573/altex.1401281,