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|Title:||Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action|
|Authors:||WILLETT Catherine; CAVERLY RAE Jessica; GOYAK Katy; MINSAVAGE Gary; WESTMORELAND Carl; ANDERSEN Melvin E.; AVIGAN Mark; DUCHÉ Daniel; Hartung T.; JAESCHKE Hartmut; KLEENSANG Andre; LANDESMANN Brigitte; TOOLE Colleen; ROWAN Andrew; SCHULTZ Terry; SEED Jennifer; SENIOR John; SHAH Imran; SUBRAMANIAN Kas; VINKEN Mathieu; WATKINS Paul|
|Citation:||ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION|
|Publisher:||SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH|
|Type:||Articles in periodicals and books|
|Abstract:||Summary The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report on “Toxicity Testing in the 21st Century: a Vision and a Strategy.” As part of its activities to further the science of pathway-based approaches to toxicity, the Human Toxicology Project Consortium convened a workshop, “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action.” Goals of the workshop were to inform 1) the process of pathway development, 2) the scope of two liver-specific pathways for liver fibrosis and steatosis developed by the European Commission Joint Research Centre, and 3) ways in which pathway approaches can be used in decision-making processes. Discussions and presentations were directed at assessing the state-of-the-art in pathway development and to build on this experience using the prototype pathways as examples.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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