Title: Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action
Authors: WILLETT CatherineCAVERLY RAE JessicaGOYAK KatyMINSAVAGE GaryWESTMORELAND CarlANDERSEN Melvin E.AVIGAN MarkDUCHÉ DanielHartung T.JAESCHKE HartmutKLEENSANG AndreLANDESMANN BrigitteTOOLE ColleenROWAN AndrewSCHULTZ TerrySEED JenniferSENIOR JohnSHAH ImranSUBRAMANIAN KasVINKEN MathieuWATKINS Paul
Citation: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
Publisher: SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH
Publication Year: 2014
JRC N°: JRC85193
ISSN: 1868-596X
URI: http://www.altex.ch/resources/WR_Willett_140217.pdf
http://publications.jrc.ec.europa.eu/repository/handle/JRC85193
DOI: 10.14573/altex.1401281
Type: Articles in periodicals and books
Abstract: Summary The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report on “Toxicity Testing in the 21st Century: a Vision and a Strategy.” As part of its activities to further the science of pathway-based approaches to toxicity, the Human Toxicology Project Consortium convened a workshop, “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action.” Goals of the workshop were to inform 1) the process of pathway development, 2) the scope of two liver-specific pathways for liver fibrosis and steatosis developed by the European Commission Joint Research Centre, and 3) ways in which pathway approaches can be used in decision-making processes. Discussions and presentations were directed at assessing the state-of-the-art in pathway development and to build on this experience using the prototype pathways as examples.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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