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dc.contributor.authorGRUBB Andersen_GB
dc.contributor.authorHORIO Masaruen_GB
dc.contributor.authorHANSSON Lars-Olofen_GB
dc.contributor.authorBJORK Jonasen_GB
dc.contributor.authorNYMAN Ulfen_GB
dc.contributor.authorFLODIN M.en_GB
dc.contributor.authorLARSSON Andersen_GB
dc.contributor.authorBÖKENKAMP Arenden_GB
dc.contributor.authorYASUDA Yoshinarien_GB
dc.contributor.authorBLUFPAND Hesteren_GB
dc.contributor.authorLINDSTROM Veronicaen_GB
dc.contributor.authorZEGERS Ingriden_GB
dc.contributor.authorALTHAUS Haralden_GB
dc.contributor.authorBLIRUP-JENSEN Sorenen_GB
dc.contributor.authorITOH Yoshien_GB
dc.contributor.authorSJÖSTRÖM Peren_GB
dc.contributor.authorNORDIN Gunnaren_GB
dc.contributor.authorCHRISTENSSON Andersen_GB
dc.contributor.authorKLIMA Horsten_GB
dc.contributor.authorSUNDE Kathrinen_GB
dc.contributor.authorHJORT-CHRISTENSEN Peren_GB
dc.contributor.authorARMBRUSTER Daviden_GB
dc.contributor.authorFerrero Carloen_GB
dc.identifier.citationCLINICAL CHEMISTRY vol. 60 no. 7 p. 974-986en_GB
dc.description.abstractBACKGROUND: Many different cystatin C–based equations exist for estimating glomerular filtration rate. Major reasons for this are the previous lack of an international cystatin C calibrator and the nonequivalence of results from different cystatin C assays. METHODS: Use of the recently introduced certified reference material, ERM-DA471/IFCC, and further work to achieve high agreement and equivalence of 7 commercially available cystatin C assays allowed a substantial decrease of the CV of the assays, as defined by their performance in an external quality assessment for clinical laboratory investigations. By use of 2 of these assays and a population of 4690 subjects, with large subpopulations of children and Asian and Caucasian adults, with their GFR determined by either renal or plasma inulin clearance or plasma iohexol clearance, we attempted to produce a virtually assay-independent simple cystatin C–based equation for estimation of GFR. RESULTS: We developed a simple cystatin C–based equation for estimation of GFR comprising only 2 variables, cystatin C concentration and age. No terms for race and sex are required for optimal diagnostic performance. The equation, eGFR=130 x cystatin C-1.069 x age-0.117 - 7, is also biologically oriented, with 1 term for the theoretical renal clearance of small molecules and 1 constant for extrarenal clearance of cystatin C. CONCLUSIONS: A virtually assay-independent simple cystatin C–based and biologically oriented equation for estimation of GFR, without terms for sex and race, was produced.en_GB
dc.description.sponsorshipJRC.D.2-Standards for Innovation and sustainable Developmenten_GB
dc.titleGeneration of a new cystatin C–based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibratoren_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Health, Consumers and Reference Materials

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