The present chapter highlights the specific challenges related to in vitro toxicity testing of nanomaterials. The difficulties presented are related to the very complex behaviour of nanomaterials during the in vitro tests, namely dissolution, aggregation, sedimentation, formation of a protein corona. All these aspects modify the physicochemical characteristics of nanomaterials, their transport to the cell layer and cellular uptake, and affect the effective cellular dose and response. The article underlines the necessity, for the toxicologist, to characterize and control all these features to be able to provide a reliable toxicity result.
KINSNER-OVASKAINEN Agnieszka;
COLPO Pascal;
PONTI Jessica;
ROSSI Francois;
2015-01-22
Springer Science+Business Media
JRC87413
978-1-4939-0520-1,
1557-2153,
http://link.springer.com/protocol/10.1007%2F978-1-4939-0521-8_21,
https://publications.jrc.ec.europa.eu/repository/handle/JRC87413,
10.1007/978-1-4939-0521-8_21,
This document is only visible at the Commission level.
You are not authorized to publish or distribute it outside the European Commission.
This is a public document. You can share this publication.
Additional supporting files
| File name | Description | File type | |
|---|
