Title: Nanotoxicology
Authors: KINSNER-OVASKAINEN AgnieszkaCOLPO PascalPONTI JessicaROSSI Francois
Publisher: Springer Science+Business Media
Publication Year: 2014
JRC N°: JRC87413
ISBN: 978-1-4939-0520-1
ISSN: 1557-2153
URI: http://link.springer.com/protocol/10.1007%2F978-1-4939-0521-8_21
http://publications.jrc.ec.europa.eu/repository/handle/JRC87413
DOI: 10.1007/978-1-4939-0521-8_21
Type: Articles in periodicals and books
Abstract: The present chapter highlights the specific challenges related to in vitro toxicity testing of nanomaterials. The difficulties presented are related to the very complex behaviour of nanomaterials during the in vitro tests, namely dissolution, aggregation, sedimentation, formation of a protein corona. All these aspects modify the physicochemical characteristics of nanomaterials, their transport to the cell layer and cellular uptake, and affect the effective cellular dose and response. The article underlines the necessity, for the toxicologist, to characterize and control all these features to be able to provide a reliable toxicity result.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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