Title: Anti-PSMA labeled liposomes loaded with Actinium-225 for potential antivascular alpha-radiotherapy
Authors: ZHU CharlesBANDEKAR AmeyBANERJEE Sangeeta RayPOMPER MartinBRUCHERTSEIFER FrankMORGENSTERN AlfredSOFOU Stavroula
Citation: JOURNAL OF NUCLEAR MEDICINE vol. 55 no. Supplement 1 p. 640
Publisher: SOC NUCLEAR MEDICINE INC
Publication Year: 2014
JRC N°: JRC88668
ISSN: 0161-5505
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC88668
Type: Articles in periodicals and books
Abstract: We study targeted liposomes loaded with the alpha-particle generator Actinium-225 (225Ac) to selectively kill prostate-specific-membrane-antigen-(PSMA)-expressing cells with the aim to evaluate their potential for targeted antivascular alpha-radiotherapy. This bottom-up design contains the following: The targeted moiety is PSMA which is unique to human tumor vasculature for several different types of primary human cancers. The therapeutic radionuclide,225Ac, emits a total of four alpha-particles per decay providing highly lethal and localized irradiation of targeted cells with minimal exposure of surrounding healthy tissues. Finally, the delivery carrier is a lipid-based nanocarrier (a liposome). Liposomes can be loaded with high levels of radioactivity, and, in terms of toxicities, liposomes can be easily engineered to become rapidly cleared from circulation with the aim to shift the distribution of normal organ toxicities away from the kidneys (the dose limiting organ for 225Ac-labeled antibodies) and toward the spleen and/or liver.
JRC Directorate:Nuclear Safety and Security

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