Title: Optimizing labeling conditions of 213Bi somatostatin analogues for receptor mediated process in preclinical models
Authors: CHAN Ho-SzeDE BLOIS ErikKONIJNENBERG M.w.MORGENSTERN AlfredBRUCHERTSEIFER FrankBREEMAN WouterDE JONG Marion
Citation: JOURNAL OF NUCLEAR MEDICINE vol. 55 no. Supplement 1 p. 1179
Publisher: SOC NUCLEAR MEDICINE INC
Publication Year: 2014
JRC N°: JRC88669
ISSN: 0161-5505
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC88669
Type: Articles in periodicals and books
Abstract: The use of alpha emitters as a therapeutic nuclide for cancer therapy becomes more interesting in the field of Nuclear Medicine. 213Bi (t1/2 = 45.6 min) is one of the most widely used alpha emitter. For receptor-mediated processes high specific activity (SA, expressed in MBq per mass ligand) is required, since the uptake is dependent on the amounts of receptors available on the tumor. However due to the radiochemical limitation; e.g. high osmolarity, large reaction volume, etc., applications to in vitro and in vivo for this processes, especially in a mouse model (<0.2 mL at 0.3 osmol in a 25 g mouse) are problematic and need adjustment. Here we present optimized labeling conditions of 213Bi-DOTA-TATE for preclinical applications. Beside optimizing the conditions, the radiochemical purity (RCP) was monitored.
JRC Directorate:Nuclear Safety and Security

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