Title: Step forward with Bi-213: Cyclen-based phosphonates show improved radiolabeling and stability
Authors: ŠIMEČEK JakubHERMANN PetrSEIDL C.MORGENSTERN AlfredNOTNI JohannesBRUCHERTSEIFER FrankWESTER Hans-Jürgen
Citation: JOURNAL OF NUCLEAR MEDICINE vol. 55 no. Supplement 1 p. 1178
Publisher: SOC NUCLEAR MEDICINE INC
Publication Year: 2014
JRC N°: JRC88672
ISSN: 0161-5505
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC88672
Type: Articles in periodicals and books
Abstract: Bi-213 is an attractive alpha-emitter for targeted radiotherapy of cancer. It is commonly introduced into small peptides via a DOTA complex, and into antibodies via CHX-A-DTPA. We investigated Bi-213-labeling efficiency, kinetics and stability of phosphonic and phosphinic acid analogs of DOTA.
JRC Directorate:Nuclear Safety and Security

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