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dc.contributor.authorCOECKE Sandraen_GB
dc.contributor.authorBOWE Gerarden_GB
dc.contributor.authorMILCAMPS Anneen_GB
dc.contributor.authorBERNASCONI Camillaen_GB
dc.contributor.authorBOSTROEM Ann-Charlotteen_GB
dc.contributor.authorBORIES Gillesen_GB
dc.contributor.authorFORTANER TORRENT Salvadoren_GB
dc.contributor.authorGINESTE Jean-Michelen_GB
dc.contributor.authorGOULIARMOU VARVARAen_GB
dc.contributor.authorLANGEZAAL Ingriden_GB
dc.contributor.authorLISKA Romanen_GB
dc.contributor.authorMENDOZA EMILIOen_GB
dc.contributor.authorMORATH Siegfrieden_GB
dc.contributor.authorREINA Vittorioen_GB
dc.contributor.authorWILK-ZASADNA IWONAen_GB
dc.contributor.authorWHELAN Mauriceen_GB
dc.date.accessioned2014-11-04T01:03:04Z-
dc.date.available2014-11-03en_GB
dc.date.available2014-11-04T01:03:04Z-
dc.date.created2014-10-27en_GB
dc.date.issued2014en_GB
dc.date.submitted2014-04-07en_GB
dc.identifier.isbn978-1-4939-0520-1en_GB
dc.identifier.issn1557-2153en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC89747-
dc.description.abstractIt has been demonstrated that the performance of in vitro toxicity testing methods can be seriously affected by variability in the essential components of the method, including the experimental protocol, the test items (chemicals), the test system (the biological models), and the analytical or measurement technique(s) used. Therefore these aspects need careful consideration during the development of in vitro methods if they are to be used in regulatory applications where compliance with quality systems is typically a prerequisite. Concerning the test system, implementation of the basic concepts of Good Cell Culture Practices (GCCP) is essential in the identification and characterisation of the biological model (test system part of the in vitro method). An adequate quality system, preferably Good Laboratory Practice (GLP) together with GCCP leads to overall Good In vitro Method Practices (GIVIM). Additional guidance for test developers will help to ensure that in vitro methods destined for regulatory use will prove to be robust, reliable and ultimately useful for supporting regulatory decisions.en_GB
dc.description.sponsorshipJRC.I.5-Systems Toxicologyen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSpringeren_GB
dc.relation.ispartofseriesJRC89747en_GB
dc.titleConsiderations in the development of in vitro toxicity testing methods intended for regulatory useen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1007/978-1-4939-0521-8_25en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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