To harmonize and standardize: making measurement results comparable

Clinical chemistry is a field where the reliability of measurement results has a major impact on decisions affecting human beings directly. The conditions under which the measurements are performed and the way their results are used bring about very stringent requirements on the methods. Measurements are expected to give reliable results after a single measurement performed directly in complex matrixes like serum or urine, and data should preferably be available within minutes or a few hours. The results need to be reliable (i.e. accurate) enough to be able to compare them within a laboratory with reference ranges and cut-off points. The main criterion however is that the measurement target is a clinically significant parameter. These requirements can currently met for hundreds of analytes.

ZEGERS Ingrid;  SCHIMMEL Heinz; 

2014-10-07

AMER ASSOC CLINICAL CHEMISTRY

JRC89820

0009-9147,   

http://www.clinchem.org/content/60/7/911,    https://publications.jrc.ec.europa.eu/repository/handle/JRC89820,   

10.1373/clinchem.2014.224477,