Glioblastoma, brain metastases and soft tissue sarcoma of extremities: Candidate tumors for BNCT
10B-concentration ratios between human glioblastoma multiforme (U87MG), sarcoma (S3) and
melanoma (MV3) xenografted in nu/nu mice and selected normal tissues were investigated to test for
preferential 10B-accumulation. Animals received BSH, BPA or both compounds sequentially. Mean
10B-concentration ratios between tumor and normal tissues above 2 were found indicating therapeutic
ratios. In addition to glioblastoma, brain metastases and soft tissue sarcoma appear to be promising
targets for future BNCT research.
WITTIG Andrea;
MOSS Raymond;
SAUERWEIN Wolfgang;
2014-09-16
PERGAMON-ELSEVIER SCIENCE LTD
JRC90186
0969-8043,
http://www.sciencedirect.com/science/article/pii/S0969804313004843,
https://publications.jrc.ec.europa.eu/repository/handle/JRC90186,
10.1016/j.apradiso.2013.11.038,
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