Title: Glioblastoma, brain metastases and soft tissue sarcoma of extremities: Candidate tumors for BNCT
Authors: WITTIG AndreaMOSS RaymondSAUERWEIN Wolfgang
Citation: APPLIED RADIATION AND ISOTOPES vol. 88 p. 46-49
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2014
JRC N°: JRC90186
ISSN: 0969-8043
URI: http://www.sciencedirect.com/science/article/pii/S0969804313004843
http://publications.jrc.ec.europa.eu/repository/handle/JRC90186
DOI: 10.1016/j.apradiso.2013.11.038
Type: Articles in periodicals and books
Abstract: 10B-concentration ratios between human glioblastoma multiforme (U87MG), sarcoma (S3) and melanoma (MV3) xenografted in nu/nu mice and selected normal tissues were investigated to test for preferential 10B-accumulation. Animals received BSH, BPA or both compounds sequentially. Mean 10B-concentration ratios between tumor and normal tissues above 2 were found indicating therapeutic ratios. In addition to glioblastoma, brain metastases and soft tissue sarcoma appear to be promising targets for future BNCT research.
JRC Directorate:Energy, Transport and Climate

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