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|Title:||Glioblastoma, brain metastases and soft tissue sarcoma of extremities: Candidate tumors for BNCT|
|Authors:||WITTIG Andrea; MOSS Raymond; SAUERWEIN Wolfgang|
|Citation:||APPLIED RADIATION AND ISOTOPES vol. 88 p. 46-49|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Type:||Articles in periodicals and books|
|Abstract:||10B-concentration ratios between human glioblastoma multiforme (U87MG), sarcoma (S3) and melanoma (MV3) xenografted in nu/nu mice and selected normal tissues were investigated to test for preferential 10B-accumulation. Animals received BSH, BPA or both compounds sequentially. Mean 10B-concentration ratios between tumor and normal tissues above 2 were found indicating therapeutic ratios. In addition to glioblastoma, brain metastases and soft tissue sarcoma appear to be promising targets for future BNCT research.|
|JRC Directorate:||Energy, Transport and Climate|
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