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|Title:||A unified framework for nanosafety is needed|
|Authors:||SCOTT-FORDSMAND Janeck; POZZI-MUCELLI Stefano; TRAN C. Lang; ASCHBERGER KARIN; SABELLA Stefania; VOGEL Ulla B; POLAND Craig; BALHARRY Dominique; FERNANDES Teresa F.; GOTTARDO STEFANIA; HANKIN Steve; HARTL Mark; HARTMANN NANNA; HRISTOZOV Danail; HUND-RINKE K.; JOHNSTON Helinor; MARCOMINI Antonio; PANZER Oliver; RONCATO Davide; SABER Anne T; WALLIN Hakan; Stone Vicki|
|Citation:||NANO TODAY vol. 9 no. 5 p. 546–549|
|Publisher:||ELSEVIER SCI LTD|
|Type:||Articles in periodicals and books|
|Abstract:||There is an urgent need for sufficient knowledge to allow reliable assessment of the risks associated with nanomaterials. The formulation of an intelligent testing strategy (ITS) that allows safety assessment across materials is required to overcome the current need of testing each nanomaterial on a case-by-case basis. By taking into consideration the research landscape, the available tools and the stakeholders involved, the ITS-NANO consortium developed a stepping-stone based research framework which can, when implemented, deliver the information required for flexible and broadly acceptable ITS and risk assessment (RA) protocols. It was identified that in order to derive this knowledge, there needs to be research emphasis on linking physicochemical identifiers to exposure and hazard identifiers, and attention should be given to a number of key cross-cutting issues have been identified which, among other things, include development of standards, dose metrics, high throughput techniques, modelling and integration into regulatory frameworks. Finally, the developed approach must be coherent and continuously updatable, supporting the unified framework required to ensure that we acquire sufficient, rigorously validated knowledge formulation of a robust reliable ITS and RA as quickly as possible. •A research framework that allows the fastest safety assessment across materials. •A stepping-stone based research framework allowing stakeholders to identify position. •Focus on establishing links between physicochemical, exposure and hazard identifiers. •Highlighting cross-cutting key issues dose metrics, high throughput and modelling. •Resulting in a coherent and continuously updatable framework supporting regulation.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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