Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and “Good ITS Practices”.

ROVIDA Costanza;  ALEPEE Nathalie;  API Anne Marie;  BASKETTER David;  BOIS Frederic Yves;  CALONI Francesca;  CORSINI Emanuela;  DANESHIAN Mardas;  ESKES Chantra;  EZENDAM Janine;  FUCHS Horst;  HAYDEN Patrick;  HEGELE-HARTUNG Christa;  HOFFMANN Sebastian;  HUBESCH Bruno;  JACOBS Miriam;  JAWORSKA Joanna;  KLEENSANG Andre;  KLEINSTREUER Nicole;  LALKO Jon;  LANDSIEDEL Robert;  LEBREUX Frederic;  LUECHTEFELD Thomas;  LOCATELLI Monica;  MEHLING Annette;  NATSCH Andreas;  PITCHFORD Jonathan W.;  PRATER Donald;  PRIETO PERAITA Maria Del Pilar;  SCHEPKY Andreas;  SCUURMANN Gerrit;  SMIRNOVA Lena;  TOOLE Colleen;  VAN VLIET Erwin;  WEISENSEE Dirk;  HARTUNG T.; 

2015-01-19

SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH

JRC91149

1868-596X,   

http://www.altex.ch/All-issues/Issue.50.html?iid=152&aid=3,    https://publications.jrc.ec.europa.eu/repository/handle/JRC91149,   

10.14573/altex.1411011,