Short commentary to "Human in vivo database now on ACuteTox home page" [Toxicology In Vitro 27 (2013) 2350–2351]

This short note concerns a statement written by Ada Kolman and Cecilia Clemedson in their publication "Human in vivo database now on ACuteTox home page" [Toxicology In Vitro 27 (2013) 2350–2351], saying that animal and in vitro data from the ACuteTox project are not yet publicly available. Having been actively involved in the ACuteTox project throughout its whole duration, as project partners and leaders of two major work-packages, we would like express our disagreement with this statement. In fact, properly evaluated and quality checked in vivo oral LD50 and in vitro data from this EU FP6 project have been available to the public before the article of Kolman and Clemedson. The acute oral toxicity animal in vivo data relevant to the 97 reference chemicals selected for the project were available in the publication by Hoffmann et al. (2010) where summaries of oral rodent LD50 data collected are provided in tables. The in vitro data generated during the course of the ACuteTox project were published in 2013 in a dedicated Special Issue of Toxicology In Vitro. All the IC50 summary values from the relevant in vitro endpoints are available in the supplementary material provided in two publications, Kinsner Ovaskainen et al., 2013 and Prieto et al., 2013 (both accessible online already in 2012).

PRIETO PERAITA Maria Del Pilar;  KINSNER-OVASKAINEN Agnieszka; 

2015-01-12

PERGAMON-ELSEVIER SCIENCE LTD

JRC92513

0887-2333,   

http://www.sciencedirect.com/science/article/pii/S0887233314002409,    https://publications.jrc.ec.europa.eu/repository/handle/JRC92513,   

10.1016/j.tiv.2014.11.016,