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dc.contributor.authorPONTI Jessicaen_GB
dc.contributor.authorKINSNER-OVASKAINEN Agnieszkaen_GB
dc.contributor.authorNORLEN H.en_GB
dc.contributor.authorALTMEYER Sandrineen_GB
dc.contributor.authorANDREOLI Cristinaen_GB
dc.contributor.authorBOGNI Alessiaen_GB
dc.contributor.authorCHEVILLARD Sylvieen_GB
dc.contributor.authorDE ANGELIS Isabellaen_GB
dc.contributor.authorCHUNG Seung-Taeen_GB
dc.contributor.authorEOM Igchunen_GB
dc.contributor.authorFUJITA Katsuhideen_GB
dc.contributor.authorGILLILAND Douglasen_GB
dc.contributor.authorGROLLINO Maria Giuseppaen_GB
dc.contributor.authorGULUMIAN Maryen_GB
dc.contributor.authorHIRSCH Cordulaen_GB
dc.contributor.authorICHIRAKU Kayoen_GB
dc.contributor.authorIGARASHI Takuyaen_GB
dc.contributor.authorJEONG Jayoungen_GB
dc.contributor.authorJO Eunhyeen_GB
dc.contributor.authorKIM Dang-Youngen_GB
dc.contributor.authorKAISER Jean-Pierreen_GB
dc.contributor.authorLAGACHE Dorisen_GB
dc.contributor.authorLA SPINA RITAen_GB
dc.contributor.authorLEE Jong Kwonen_GB
dc.contributor.authorLEE Jieunen_GB
dc.contributor.authorLOVERA Annalisaen_GB
dc.contributor.authorMÄDER-ALTHAUS Xeniaen_GB
dc.contributor.authorNESSLANY Fabriceen_GB
dc.contributor.authorOJEA JIMENEZ ISAACen_GB
dc.contributor.authorPACCHIEROTTI Francescaen_GB
dc.contributor.authorPIANELLA FRANCESCAen_GB
dc.contributor.authorPAGET Vincenten_GB
dc.contributor.authorKIM Tae Rimen_GB
dc.contributor.authorROSZAK Joannaen_GB
dc.contributor.authorROSENKRANZ PHILIPPen_GB
dc.contributor.authorSIMAR Sophieen_GB
dc.contributor.authorSTĘPNIK Maciejen_GB
dc.contributor.authorVETTEN Melissaen_GB
dc.contributor.authorSONG Nam Woongen_GB
dc.contributor.authorYANG Jun-Youngen_GB
dc.contributor.authorROSSI Francoisen_GB
dc.contributor.editorKINSNER-OVASKAINEN Agnieszkaen_GB
dc.contributor.editorPONTI Jessicaen_GB
dc.date.accessioned2015-03-12T01:03:49Z-
dc.date.available2015-03-11en_GB
dc.date.available2015-03-12T01:03:49Z-
dc.date.created2015-02-25en_GB
dc.date.issued2014en_GB
dc.date.submitted2014-12-15en_GB
dc.identifier.isbn978-92-79-44677-1en_GB
dc.identifier.issn1831-9424en_GB
dc.identifier.otherEUR 27009en_GB
dc.identifier.otherOP LB-NA-27009-EN-Nen_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC92910-
dc.description.abstractNanotechnology has gained importance in the past years as it provides opportunities for industrial growth and innovation. However, the increasing use of manufactured nanomaterials (NMs) in a number of commercial applications and consumer products raises also safety concerns and questions regarding potential unintended risks to humans and the environment. Since several years the European Commission’s Joint Research Centre (JRC) is putting effort in the development, optimisation and harmonisation of in vitro test methods suitable for screening and hazard assessment of NMs. Work is done in collaboration with international partners, in particular the Organisation for Economic Co-operation and Development (OECD). This report presents the results from an interlaboratory comparison study of the in vitro Colony Forming Efficiency (CFE) cytotoxicity assay performed in the frame of OECD's Working Party of Manufactured Nanomaterials (WPMN). Twelve laboratories from European Commission, France, Italy, Japan, Poland, Republic of Korea, South Africa and Switzerland participated in the study coordinated by JRC. The results show that the CFE assay is a suitable and robust in vitro method to assess cytotoxicity of NMs. The assay protocol is well defined and is easily and reliably transferable to other laboratories. The results obtained show good intra and interlaboratory reproducibility of the assay for both the positive control and the tested nanomaterials. In conclusion the CFE assay can be recommended as a building block of an in vitro testing battery for NMs toxicity assessment. It could be used as a first choice method to define dose-effect relationships for other in vitro assays.en_GB
dc.description.sponsorshipJRC.I.4-Nanobiosciencesen_GB
dc.format.mediumOnlineen_GB
dc.languageENGen_GB
dc.publisherPublications Office of the European Unionen_GB
dc.relation.ispartofseriesJRC92910en_GB
dc.titleInterlaboratory comparison study of the Colony Forming Efficiency assay for assessing cytotoxicity of nanomaterialsen_GB
dc.typeEUR - Scientific and Technical Research Reportsen_GB
dc.identifier.doi10.2788/406937en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection



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