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dc.contributor.authorPRICE Annaen_GB
dc.contributor.authorCROFTON Kevin Men_GB
dc.contributor.authorLEIST Marcelen_GB
dc.contributor.authorALLEN Sandraen_GB
dc.contributor.authorARAND Michaelen_GB
dc.contributor.authorBUETLER Timoen_GB
dc.contributor.authorDELRUE Nathalieen_GB
dc.contributor.authorFITZGERALD Rexen_GB
dc.contributor.authorHARTUNG Thomasen_GB
dc.contributor.authorHEINONEN Tuulaen_GB
dc.contributor.authorHOGBERG Helenaen_GB
dc.contributor.authorHOUGAARD BENNEKOU Susanneen_GB
dc.contributor.authorLICHTENSTEIGER Walteren_GB
dc.contributor.authorOGGIER Danielaen_GB
dc.contributor.authorPAPARELLA Martinen_GB
dc.contributor.authorAXELSTAD Martaen_GB
dc.contributor.authorPIERSMA Alderten_GB
dc.contributor.authorRACHED Evaen_GB
dc.contributor.authorSCHILTER Benoîten_GB
dc.contributor.authorSCHMUCK Gabrieleen_GB
dc.contributor.authorSTOPPINI Lucen_GB
dc.contributor.authorTONGIORGI Enricoen_GB
dc.contributor.authorTIRAMANI Manuelaen_GB
dc.contributor.authorMONNET-TSCHUDI Florianneen_GB
dc.contributor.authorWILKS Martinen_GB
dc.contributor.authorYLIKOMI Timoen_GB
dc.contributor.authorFRITSCHE Ellenen_GB
dc.date.accessioned2015-05-28T10:23:19Z-
dc.date.available2015-02-12en_GB
dc.date.available2015-05-28T10:23:19Z-
dc.date.created2015-02-10en_GB
dc.date.issued2015en_GB
dc.date.submitted2014-12-12en_GB
dc.identifier.citationARCHIVES OF TOXICOLOGY vol. 89 no. 2 p. 269-287en_GB
dc.identifier.issn0340-5761en_GB
dc.identifier.urihttp://link.springer.com/article/10.1007%2Fs00204-015-1464-2en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC93454-
dc.description.abstractA major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test systems and methods on the other hand. Alignment of academically and industrially-driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISNET) in DNT testing. The first meeting of ISTNET was held in Zurich on 23-24 January 2014 in order to explore the concept of adverse outcome pathway (AOP) to practical DNT testing. AOPs were considered promising tools to promote test systems development according to regulatory needs. Moreover, the AOP concept was identified as an important guiding principle to assemble predictive integrated testing strategies (ITSs) for DNT. The recommendations on a roadmap towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment. Next steps to be considered in follow-up activities are the use of case studies to further apply the AOP concept in regulatory DNT testing, making use of AOP intersections (common key events) for economic development of screening assays, and addressing the transition from qualitative descriptions to quantitative network modelling.en_GB
dc.description.sponsorshipJRC.I.5-Systems Toxicologyen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSPRINGER HEIDELBERGen_GB
dc.relation.ispartofseriesJRC93454en_GB
dc.titleInternational STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposesen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1007/s00204-015-1464-2en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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