Title: Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making
Authors: BERGGREN ELISABETAMCOFF PatricBENIGNI RomualdoBLACKBURN KarenCARNEY EdwardCRONIN MarkDELUYKER HubertGAUTIER FrancoiseJUDSON RichardKASS GeorgeKELLER DetleffKNIGHT DerekLILIENBLUM WernerMAHONY CatherineRUSYN IvanSCHULTZ TerrySCHWARZ MichaelSCHÜÜRMANN GerritWHITE A.BURTON JULIENLOSTIA ALFONSOMUNN SHARONWORTH Andrew
Citation: ENVIRONMENTAL HEALTH PERSPECTIVES vol. 123 no. 12 p. 1232-1240
Publisher: US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
Publication Year: 2015
JRC N°: JRC94006
ISSN: 0091-6765
URI: http://ehp.niehs.nih.gov/1409342/
http://publications.jrc.ec.europa.eu/repository/handle/JRC94006
DOI: 10.1289/ehp.1409342
Type: Articles in periodicals and books
Abstract: Background: Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the Proof-of-Concept ambitions of SEURAT-1, the largest ever EU research initiative on alternative testing, co-funded by the European Commission and Cosmetics Europe. This paper is based on the discussion and outcome of a workshop organised on initiative of the SEURAT-1 consortium joined by a group of international experts with complementary knowledge to further develop traditional read-across and include new approach data. Objectives: The aim of the suggested strategy for chemical read-across is to show how a traditional read-across based on structural similarities between source and target substance can be strengthened with additional evidence from new approach data, e.g., information from in vitro molecular screening, '-omics' assays and computational models, to reach regulatory acceptance. Methods: We identified four read-across scenarios that cover typical human health assessment situations. For each such decision context, we suggested several chemical groups as examples to prove when read-across is possible or not between group members considering both chemical and biological similarities. Conclusions: We agreed to carry out the complete read-across exercise for one chemical category per read-across scenario in the context of SEURAT-1 and the results of this exercise will be completed and presented by the end of the research initiative in December 2015. External collaborative partners are invited to follow the same systematic read-across approach and to contribute to the final Proof-of-Concept.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.