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dc.contributor.authorSPAMPINATO VALENTINAen_GB
dc.contributor.authorCECCONE Giacomoen_GB
dc.contributor.authorGIORDANI Silviaen_GB
dc.date.accessioned2015-12-23T01:33:52Z-
dc.date.available2015-12-21en_GB
dc.date.available2015-12-23T01:33:52Z-
dc.date.created2015-12-15en_GB
dc.date.issued2015en_GB
dc.date.submitted2015-01-22en_GB
dc.identifier.citationBIOINTERPHASES vol. 10 no. 1 p. 019006en_GB
dc.identifier.issn1934-8630en_GB
dc.identifier.urihttp://scitation.aip.org/content/avs/journal/bip/10/1/10.1116/1.4907726en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC94596-
dc.description.abstractMultishell fullerenes, known as carbon nano-onions (CNOs), are an interesting class of carbon-based nanomaterials. They display several unique properties, such as a large surface area to volume ratio, a low density and a graphitic multilayer morphology, which have made them appealing for several applications in many fields, including biology. Chemical functionalization of CNOs dramatically enhances their solubility and attenuates their inflammatory properties, thereby increasing their applicability especially in the fields of biology and medicine. CNOs functionalized with fluorescent probes can be used for cellular imaging. In this article, detailed surface characterization of CNOs functionalized with a zinc porphyrin (ZnTPP) as the fluorescent probe is presented. In particular, Time-of-Flight Secondary Ion Mass Spectrometry and X-ray Photoelectron Spectroscopy provide a detailed surface characterization of the organic functionalities introduced via “click chemistry” and clearly demonstrate the success of the CNOs functionalization process. XPS data reveal the presence of Zn and N, whilst ToF-SIMS is able to identify specific fragments related to the presence of the ZnTPP, such as the quasi-molecular mass peak [C32N4H20Zn]+ and the molecular mass peak [C44N4H28Zn]+. Moreover, ions fragments deriving from the triazole ring formed by the click chemistry reaction have been identified by ToF-SIMS analysis, proving unambiguously the covalent binding of the fluorescent molecules to the CNOs surfacesen_GB
dc.description.sponsorshipJRC.I.4-Nanobiosciencesen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSPRINGERen_GB
dc.relation.ispartofseriesJRC94596en_GB
dc.titleSurface analysis of zinc-porphyrin functionalized carbon nano-onionsen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1116/1.4907726en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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