Title: High-resolution scanning transmission soft X-ray microscopy for rapid probing of nanoparticle distribution and sufferance features in exposed cells
Authors: KOUROUSIAS GPASCOLO LorellaMARMORATO PatrickPONTI JessicaCECCONE GiacomoKISKINOVA MayaGIANONCELLI Alessandra
Citation: X-RAY SPECTROMETRY vol. 44 no. 3 p. 163-168
Publisher: WILEY-BLACKWELL
Publication Year: 2015
JRC N°: JRC94597
ISSN: 0049-8246
URI: http://onlinelibrary.wiley.com/doi/10.1002/xrs.2595/abstract;jsessionid=2C68AF22CEC0555817BBC30A1EEB0FC6.f04t04
http://publications.jrc.ec.europa.eu/repository/handle/JRC94597
DOI: 10.1002/xrs.2595
Type: Articles in periodicals and books
Abstract: Refraction and absorption properties of soft X-rays provide distinct advantages for ‘fast’ imaging of matter consisting of light elements, as biological samples, with sensitivity better than conventional light microscopy. This is very attractive for nanotoxicology, in particular for rapid screening of nanoparticle distribution and their effects on exposed cells at submicrometer length scales. In this paper we report on the first trials demonstrating the potential of Scanning Transmission X-ray microscopy to monitor morphological and chemical changes induced in Balb 3T3 mouse fibroblast cells exposed toCoFe2O4nanoparticles. This research uses the complementary imaging methods of an advanced synchrotron soft X-ray microscopy instrument implementing a novel approach based on high resolution absorption and phase contrast imaging for the identification of important cellular changes induced by the presence of nanoparticles.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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