Title: Improved spheroid penetration of alpha-particle emitters by diffusing tunable liposomes forpotential alpha-radiotherapy of solid tumors
Authors: ZHU CharlesHOLLERAN TimothyBRUCHERTSEIFER FrankMORGENSTERN AlfredSOFOU Stavroula
Citation: JOURNAL OF NUCLEAR MEDICINE vol. 56 no. S3 p. 1197
Publisher: SOC NUCLEAR MEDICINE INC
Publication Year: 2015
JRC N°: JRC94666
ISSN: 0161-5505
URI: http://jnm.snmjournals.org/content/56/supplement_3.toc
http://publications.jrc.ec.europa.eu/repository/handle/JRC94666
Type: Articles in periodicals and books
Abstract: In solid tumors, the limited penetration of radionuclide carriers prohibits the use of alpha-particles due to their short range which would result in partial tumor irradiation with limited killing efficacy. However, excluding transport considerations, alphas are extremely potent. To explore the potential of alphas against solid tumors, we study non-targeted liposomes that are triggered to release highly-diffusive forms of the alpha-particle generator Actinium-225 (Ac-225) within the tumor interstitium. The rationale is that nanometer-sized liposome carriers would enable enhanced (heterogeneous) uptake of radioactivity by the tumor, and that the triggered release of encapsulated Ac-225 within the interstitium would result in deeper penetration of the alpha-emitter improving uniformity in tumor irradiation.
JRC Directorate:Nuclear Safety and Security

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