In solid tumors, the limited penetration of radionuclide carriers prohibits the use of alpha-particles due to their short range which would result in partial tumor irradiation with limited killing efficacy. However, excluding transport considerations, alphas are extremely potent.
To explore the potential of alphas against solid tumors, we study non-targeted liposomes that are triggered to release highly-diffusive forms of the alpha-particle generator Actinium-225 (Ac-225) within the tumor interstitium. The rationale is that nanometer-sized liposome carriers would enable enhanced (heterogeneous) uptake of radioactivity by the tumor, and that the triggered release of encapsulated Ac-225 within the interstitium would result in deeper penetration of the alpha-emitter improving uniformity in tumor irradiation.
ZHU Charles;
HOLLERAN Timothy;
BRUCHERTSEIFER Frank;
MORGENSTERN Alfred;
SOFOU Stavroula;
2015-07-14
SOC NUCLEAR MEDICINE INC
JRC94666
0161-5505,
http://jnm.snmjournals.org/content/56/supplement_3.toc,
https://publications.jrc.ec.europa.eu/repository/handle/JRC94666,
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