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dc.contributor.authorZHU Charlesen_GB
dc.contributor.authorHOLLERAN Timothyen_GB
dc.contributor.authorBRUCHERTSEIFER Franken_GB
dc.contributor.authorMORGENSTERN Alfreden_GB
dc.contributor.authorSOFOU Stavroulaen_GB
dc.date.accessioned2015-07-15T00:12:57Z-
dc.date.available2015-07-14en_GB
dc.date.available2015-07-15T00:12:57Z-
dc.date.created2015-06-11en_GB
dc.date.issued2015en_GB
dc.date.submitted2015-01-29en_GB
dc.identifier.citationJOURNAL OF NUCLEAR MEDICINE vol. 56 no. S3 p. 1197en_GB
dc.identifier.issn0161-5505en_GB
dc.identifier.urihttp://jnm.snmjournals.org/content/56/supplement_3.tocen_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC94666-
dc.description.abstractIn solid tumors, the limited penetration of radionuclide carriers prohibits the use of alpha-particles due to their short range which would result in partial tumor irradiation with limited killing efficacy. However, excluding transport considerations, alphas are extremely potent. To explore the potential of alphas against solid tumors, we study non-targeted liposomes that are triggered to release highly-diffusive forms of the alpha-particle generator Actinium-225 (Ac-225) within the tumor interstitium. The rationale is that nanometer-sized liposome carriers would enable enhanced (heterogeneous) uptake of radioactivity by the tumor, and that the triggered release of encapsulated Ac-225 within the interstitium would result in deeper penetration of the alpha-emitter improving uniformity in tumor irradiation.en_GB
dc.description.sponsorshipJRC.E.5-Nuclear chemistryen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSOC NUCLEAR MEDICINE INCen_GB
dc.relation.ispartofseriesJRC94666en_GB
dc.titleImproved spheroid penetration of alpha-particle emitters by diffusing tunable liposomes forpotential alpha-radiotherapy of solid tumorsen_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Nuclear Safety and Security

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