Title: Review of achievements of the OECD Working Party on Manufactured Nanomaterials' Testing and Assessment Programme. From exploratory testing to test guidelines
Authors: RASMUSSEN KirstenGONZALEZ MarKEARNS PeterRIEGO SINTES JuanROSSI FrancoisSAYRE Phil
Citation: REGULATORY TOXICOLOGY AND PHARMACOLOGY vol. 74 p. 147-160
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Year: 2016
JRC N°: JRC94828
ISSN: 0273-2300
URI: http://www.sciencedirect.com/science/article/pii/S0273230015301197
http://publications.jrc.ec.europa.eu/repository/handle/JRC94828
DOI: 10.1016/j.yrtph.2015.11.004
Type: Articles in periodicals and books
Abstract: This paper charts the almost ten years of history of OECD's work on nanosafety, during which the programme of the OECD on the Testing and Assessment of Manufactured Nanomaterials covered the testing of eleven nanomaterials for about 59 end-points addressing physicalechemical properties, mammalian and environmental toxicity, environmental fate and material safety. An overview of the materials tested, the test methods applied and the discussions regarding the applicability of the OECD test guidelines, which are recognised methods for regulatory testing of chemicals, are given. The results indicate that many existing OECD test guidelines are suitable for nanomaterials and consequently, hazard data collected using such guidelines will fall under OECD's system of Mutual Acceptance of Data (MAD) which is a legally binding instrument to facilitate the international acceptance of information for the regulatory safety assessment of chemicals. At the same time, some OECD test guidelines and guidance documents need to be adapted to address nanomaterials while new test guidelines and guidance documents may be needed to address endpoints that are more relevant to nanomaterials. This paper presents examples of areas where test guidelines or guidance for nanomaterials are under development.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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