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dc.contributor.authorBURDEN Natalieen_GB
dc.contributor.authorSEWELL Fionaen_GB
dc.contributor.authorANDERSEN Melvin E.en_GB
dc.contributor.authorBOOBIS Alan R.en_GB
dc.contributor.authorCHIPMAN Kevinen_GB
dc.contributor.authorCRONIN Marken_GB
dc.contributor.authorHUTCHINSON Thomasen_GB
dc.contributor.authorKIMBER Ianen_GB
dc.contributor.authorWHELAN Mauriceen_GB
dc.date.accessioned2016-08-07T00:04:35Z-
dc.date.available2016-08-05en_GB
dc.date.available2016-08-07T00:04:35Z-
dc.date.created2016-08-02en_GB
dc.date.issued2015en_GB
dc.date.submitted2015-06-03en_GB
dc.identifier.citationJOURNAL OF APPLIED TOXICOLOGY vol. 35 no. 9 p. 971–975en_GB
dc.identifier.issn0260-437Xen_GB
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/jat.v35.9/issuetocen_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC96049-
dc.description.abstractAdverse Outcome Pathways (AOPs) provide an opportunity to develop newand more accurate safety assessment processes for drugs and other chemicals, and may ultimately play an important role in regulatory decision making. Not only can the development and application of AOPs pave theway for the development of improved evidence-based approaches for hazard and risk assessment, there is also the promise of a significant impact on animal welfare, with a reduced reliance on animal-based methods. The establishment of a useable and coherent knowledge framework under which AOPs will be developed and applied has been a first critical step towards realizing this opportunity. This article explores how the development of AOPs under this framework, and their application in practice, could benefit the science and practice of safety assessment, while in parallel stimulating a move away from traditional methods towards an increased acceptance of non-animal approaches. We discuss here the key areas where current, and future initiatives should be focused to enable the translation of AOPs into routine chemical safety assessment, and lasting 3Rs benefits.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.format.mediumOnlineen_GB
dc.languageENGen_GB
dc.publisherWILEY-BLACKWELLen_GB
dc.relation.ispartofseriesJRC96049en_GB
dc.titleAdverse Outcome Pathways can drive non-animal approaches for safety assessmenten_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1002/jat.3165en_GB
JRC Directorate:Health, Consumers and Reference Materials

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