Identification of Substances of Very High Concern (SVHC) under the 'equivalent level of concern' route (REACH Article 57(f)) - neurotoxicants and immunotoxicants as examples
This report analyses whether substances classified for specific target organ toxicity (STOT) according Regulation 1272/2008 on Classification, Labelling and Packaging, in particular those causing immunotoxic or neurotoxic effects, would be eligible to be identified as substances of very high concern (SVHC) under the 'equivalent level of concern' route set out in Article 57(f) of REACH Regulation (EC) No 1907/2006 (Registration, Evaluation, Authorisation and Restriction of Chemicals). This document attempts to identify, characterise and compare the 'level of concern' that exists for immunotoxic and neurotoxic substances with that of CMRs (carcinogens, mutagens and/or reproductive toxicants). The comparison considers the seriousness, irreversibility and delay of hazardous effects, together with other factors, such as the quality of life affected, consequences for society and the possibility to derive a safe concentration.
QUIROS PESUDO Laia;
ASCHBERGER Karin;
2015-08-20
Publications Office of the European Union
JRC96572
978-92-79-50319-1,
1831-9424,
EUR 27383,
OP LB-NA-27383-EN-N,
https://publications.jrc.ec.europa.eu/repository/handle/JRC96572,
10.2788/080027,
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