Radioimmunothérapie alpha
Principes et intérêts en immunité antitumorale
Alpha-radioimmunotherapy (α-RIT) is a targeted anti-tumor therapy using usually a monoclonal antibody specific for a tumor antigen that is coupled to an α-particle emitter. α-emitters represent an ideal tool to eradicate disseminated tumors or metastasis. Recent data demonstrate that ionizing radiation in addition to its direct cytotoxic ability can also induce an efficient anti-tumor immunity. This suggests that biologic effects on irradiated tissues could be used to potentiate immunotherapy efficacy and open door to development of new therapies combining α-RIT and different types of immunotherapy.
MENAGER J;
GORIN J;
FICHOU Nolwenn;
GOUARD S.;
MORGENSTERN Alfred;
BRUCHERTSEIFER Frank;
DAVODEAU F;
KRAEBER BODÉRÉ F;
CHEREL M.;
GASCHET J;
GUILLOUX Yannick;
2016-06-22
EDP Sciences
JRC97048
0767-0974,
https://publications.jrc.ec.europa.eu/repository/handle/JRC97048,
10.1051/medsci/20163204014,
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