SEURAT-1 Proof of Concepts

The SEURAT vision is to fundamentally change the way we assess the safety of chemicals, by superseding traditional animal experiments with a predictive toxicology that is based on a comprehensive understanding of how chemicals can cause adverse effects in humans (Whelan & Schwarz, 2011). The SEURAT strategy is to adopt a toxicological mode-of-action framework to describe how any substance may adversely affect human health, and to use this knowledge to develop complementary theoretical, computational and experimental (in vitro) models that predict quantitative points of departure needed for safety assessment. One of the SEURAT-1 objectives is to demonstrate a multiple level proof-of-concept (theoretical, methodological, and application; Whelan & Schwarz, 2012; 2013). This chapter in the annual report is outlining the progress in the activities to develop the SEURAT-1 proof-of-concept.

BERGGREN Elisabet; 

2016-01-21

Arttic

JRC97188

978-2-9539634-4-1,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC97188,