Title: Multiscale modelling approaches for assessing cosmetic ingredients safety
Authors: BOIS FREDERIC YVESDIAZ OCHOA JUAN GUILLERMOGAJEWSKA MONIKAKOVARICH SIMONAMAUCH KLAUSPAINI ALICIAPERY ALEXANDRESALA BENITO JOSE'TENG SOPHIEWORTH ANDREW
Citation: TOXICOLOGY vol. 392 p. 130-139
Publisher: ELSEVIER IRELAND LTD
Publication Year: 2015
JRC N°: JRC97860
ISSN: 0300-483X
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC97860
DOI: 10.1016/j.tox.2016.05.026
Type: Articles in periodicals and books
Abstract: The European Union's ban on animal testing for cosmetic ingredients and products has generated a strong momentum for the development of in silico and in vitro alternative methods. One of the focus of the COSMOS project was ab initio prediction of kinetics and toxic effects through multiscale pharmacokinetic modeling and in vitro data integration. In our experience, mathematical or computer modelling and in vitro experiments are complementary. We present here a summary of the main models and results obtained within the framework of the project on these topics. A first section presents our work at the organelle and cellular level. We then go toward modeling cell levels effects (monitored continuously), multiscale physiologically based pharmacokinetic and effect models, and route to route extrapolation. We follow with a short presentation of the automated KNIME workflows developed for dissemination and easy use of the models. We end with a discussion of two challenges to the field: our limited ability to deal with massive data and complexcomputations.
JRC Directorate:Health, Consumers and Reference Materials

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