The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the identification of predictive genomics biomarkers of functional relevance for drug-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).
CHAUDHARI Umesh;
NEMADE Harshal;
WAGH Vilas;
GASPAR John;
ELLIS James K;
SRINIVASAN Sureshkumar;
SPITKOVSKI Dimitry;
NGUEMO Filomain;
LOUISSE Jochem;
BREMER Susanne;
HESCHELER Juergen;
KEUN Hector;
HENGSTLER Jan;
SACHINIDIS Agapios;
2016-12-07
SPRINGER HEIDELBERG
JRC97997
0340-5761,
https://publications.jrc.ec.europa.eu/repository/handle/JRC97997,
10.1007/s00204-015-1623-5,
This document is only visible at the Commission level.
You are not authorized to publish or distribute it outside the European Commission.
This is a public document. You can share this publication.
Additional supporting files
| File name | Description | File type | |
|---|
