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|Title:||Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment|
|Authors:||CHAUDHARI Umesh; NEMADE Harshal; WAGH Vilas; GASPAR John; ELLIS James K; SRINIVASAN Sureshkumar; SPITKOVSKI Dimitry; NGUEMO Filomain; LOUISSE JOCHEM; BREMER Susanne; HESCHELER Juergen; KEUN Hector; HENGSTLER Jan; SACHINIDIS Agapios|
|Citation:||ARCHIVES OF TOXICOLOGY vol. 90 p. 2763-2777|
|Type:||Articles in periodicals and books|
|Abstract:||The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the identification of predictive genomics biomarkers of functional relevance for drug-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).|
|JRC Directorate:||Health, Consumers and Reference Materials|
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