Title: Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
Authors: CHAUDHARI UmeshNEMADE HarshalWAGH VilasGASPAR JohnELLIS James KSRINIVASAN SureshkumarSPITKOVSKI DimitryNGUEMO FilomainLOUISSE JOCHEMBREMER SusanneHESCHELER JuergenKEUN HectorHENGSTLER JanSACHINIDIS Agapios
Citation: ARCHIVES OF TOXICOLOGY vol. 90 p. 2763-2777
Publisher: SPRINGER HEIDELBERG
Publication Year: 2016
JRC N°: JRC97997
ISSN: 0340-5761
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC97997
DOI: 10.1007/s00204-015-1623-5
Type: Articles in periodicals and books
Abstract: The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the identification of predictive genomics biomarkers of functional relevance for drug-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).
JRC Directorate:Health, Consumers and Reference Materials

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