Gold nanoparticles increases UV and thermal stability of human serum albumin
Ultraviolet (UV) radiation, temperature, and time can degrade proteins. Here we show that gold nanoparticles significantly protect human serum albumin (HSA) from denaturation when exposed to “stressing” conditions such as UV irradiation and sustained exposure in sub-optimal conditions. In particular, we show that gold nanoparticles significantly reduce the decrease in secondary structure induced by UV irradiation or extended exposure to ambient temperature.
CAPOMACCIO Robin Bruno;
OSORIO Ines;
OJEA JIMENEZ Isaac;
CECCONE Giacomo;
COLPO Pascal;
GILLILAND Douglas;
HUSSAIN Rohanah;
SILIGARDI Giuliano;
ROSSI Francois;
RICARD-BLUM Sylvie;
CALZOLAI Luigi;
2017-02-09
AMER INST PHYSICS
JRC98173
1934-8630,
http://dx.doi.org/10.1116/1.4972113,
https://publications.jrc.ec.europa.eu/repository/handle/JRC98173,
10.1116/1.4972113,
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