Title: The 3Rs as a framework to support a 21st century approach for nanosafety assessment
Authors: BURDEN NatalieASCHBERGER KARINCHAUDHRY QasimCLIFT Martin J. D.DOAK Shareen H.FOWLER PaulJOHNSTON HelinorLANDSIEDEL RobertROWLAND JoannaSTONE Vicki
Citation: NANO TODAY vol. 12 p. 10-13
Publisher: ELSEVIER SCI LTD
Publication Year: 2015
JRC N°: JRC98878
ISSN: 1748-0132
URI: http://ac.els-cdn.com/S1748013215301079/1-s2.0-S1748013215301079-main.pdf?_tid=75a10424-f2b3-11e6-a4dc-00000aacb35d&acdnat=1487076507_6f6321e144138ff2ceb421b99fd30ea4
http://publications.jrc.ec.europa.eu/repository/handle/JRC98878
DOI: 10.1016/j.nantod.2016.06.007
Type: Articles in periodicals and books
Abstract: Due to the plethora of nanomaterials being manufactured, it is crucial that their effects on human health are understood. It is not feasible to assess the safety of all nanomaterials using animal-based toxicity tests. There are also scientific, business, legislative and ethical drivers to reconsider the use of such toxicity tests. Utilising non-traditional methods has the potential to improve the human relevance of nanosafety assessment, reduce the numbers of animals that are used, and shift the paradigm to a ‘21st century’ approach that exploits recent scientific and technological advances. This article considers how application of the 3Rs principles can be used as a framework to support and guide this paradigm shift in the short, medium and long-term. Bringing the community together to facilitate the transition is necessary to ensure that tangible impacts are made on the efficiency and robustness of the nanosafety assessment process.
JRC Directorate:Health, Consumers and Reference Materials

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