The validation of an analytical method is a necessary step in controlling the quality of quantitative analysis. Method validation is an established process which provides documentary evidence that a system fulfils its pre-defined specification, or shows that an analytical method is acceptable for its intended purpose. The purpose of the present study was to develop and validate analytical procedures for the quantitative determination in recycled and wastewater samples of substances selected in the framework of the exploratory project iDRIP. Analyte extraction was performed using a JRC in-house developed sampling device for on-site solid phase extraction of water samples. Two instrumental methods were developed and validated:
• a multi-residual method based on LC-MS/MS analysis for quantitative determination of selected contaminants of emerging concern (CECs), including: acesulfame K, sucralose, estrone, 17-estradiol, 17-ethynyl estradiol carbamazepine, 10,11-dihydro 10,11-dihydroxy carbamazepine, diclofenac, ibuprofen, sulfamethazine and sulfamethoxazole in recycled and wastewater samples;
• a multi-residual method based on GC-MS analysis for quantitative determination of selected organophosphorous compounds (OPCs).
Selectivity, detection and quantification limits, linearity study, matrix comparison, repeatability and intermediate precision, variability of trueness and recoveries were determined for CECs and OPC compounds.
TAVAZZI Simona;
MARIANI Giulio;
SKEJO Helle;
LOBO PEREIRA VICENTE Joana;
CHASSAIGNE Hubert;
VANDECASTEELE Ine;
COMERO Sara;
GAWLIK Bernd;
2017-05-11
Publications Office of the European Union
JRC106366
978-92-79-68454-8 (print),
978-92-79-68455-5,
1018-5593 (print),
1831-9424 (online),
EUR 28573 EN,
OP KJ-NA-28573-EN-C (print),
OP KJ-NA-28573-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC106366,
10.2760/70591 (print),
10.2760/55150 (online),
