Recoil retention and therapeutic efficacy of 225Ac-containing polymersomes
Alpha emitters can play an important role in cancer treatment. With their high linear energy transfer and short range, alpha particles are ideal for localized cell killing. However, upon emission of an alpha particle, the radioactive daughter nuclides experience a recoil energy of about 100-200 keV which is much larger than the energy of any chemical bond, resulting in the daughter nuclide breaking free from any targeting agent. These daughters can accumulate in healthy tissue as kidneys, resulting in toxicity. Here, we evaluate the retention of recoiling daughter 213Bi of 225Ac entrapped in polymersomes in vivo, both upon intravenous as well as intratumoral administration. Furthermore, the suitability of 225Ac-containing PBD-PEO (poly-butadiene-poly-ethylene oxide) polymersomes as therapeutic agents is assessed upon intratumoral injection.
RAAVÉ R;
DE KRUIJFF R. M.;
KIP Annemarie;
MOLKENBOER- KUENEN Jannike;
MORGENSTERN Alfred;
BRUCHERTSEIFER Frank;
HESKAMP Sandra;
DENKOVA A.G.;
2019-10-30
SPRINGER
JRC116615
1619-7070 (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC116615,
10.1007/s00259-019-04486-2 (online),
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