In Silico Approaches In Carcinogenicity Hazard Assessment: Current Status and Future Needs
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. In silico models have been developed for predicting rodent carcinogens but have not yet found general regulatory acceptance, in part due to the lack of a generally accepted protocol for performing such an assessment as well as limitations in predictive performance and scope. There remains a need for additional, improved in silico carcinogenicity models, especially ones that are more human-relevant, for use in research and regulatory decision-making. As part of an international effort to develop in silico toxicological protocols, a consortium of toxicologists, computational scientists, and regulatory scientists across several industries and governmental agencies evaluated the extent to which in silico models exist for each of the recently defined 10 key characteristics (KCs) of carcinogens. This position paper summarizes the current status of in silico tools for the assessment of each KC and identifies the data gaps that need to be addressed before a comprehensive in silico carcinogenicity protocol can be developed for regulatory use.
TICE Raymond R.;
BASSAN Arianna;
AMBERG Alexander;
ANGER Lennart T;
BEAL Marc A;
BELLION Phillip;
BENIGNI Romualdo;
BIRMINGHAN Jeffrey;
BRIGO Alessandro;
BRINGEZU Frank;
CERIANI Lidia;
CROOKS Ian;
CROSS Kevin P.;
ELESPURU Rosalie;
FAULKNER David;
FORTIN Marie C;
FOWLER Paul;
FRERICKS Markus;
GERETS Helga;
JAHNKE Gloria D;
JONES David;
KRUHLAK Naomi;
LO PIPARO Elena;
LOPEZ-BELMONTE Juan;
LUNIWAL Amarjit;
LUU Alice;
MADIA Federica Anna Carla;
MANGANELLI Serena;
MANICKAM Balasubramaniam;
MESTRES Jordi;
MIHALCHIK-BURHANSAD Amy L;
NEILSON Louise;
PANDIRI Arun;
PAVAN Manuela;
RIDER Cynthia V;
ROONEY John P;
TREJO-MARTIN Alejandra;
WATANABE-SAILOR Karen H;
WHITE Angela T;
WOOLLEY David;
MYATT Glenn;
2021-10-05
ELSEVIER BV
JRC122817
2468-1113 (print),
https://publications.jrc.ec.europa.eu/repository/handle/JRC122817,
10.1016/j.comtox.2021.100191 (online),
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