Information concerning the longevity of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in convalescent coronavirus disease-2019 (COVID-19) patients up to 15 months after symptoms onset. Following a peak at day 15-28 post-infection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants of concern. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells was observed between 6 and 15 months. The data suggest that antiviral specific immunity especially memory B cells in COVID-19 convalescent patients is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.
MARCOTTE Harold;
PIRALLA Antonio;
ZUO Fanglei;
DU Likun;
CASSANITI Irene;
WAN Hui;
KUMAGAI BRAESH Makiko;
ANDRELL Juni;
PERCIVALLE Elena;
SAMMARTINO Josè;
WANG Yating;
VLACHIOTIS Stelios;
ATTEVALL Janine;
BERGAMI Federica;
FERRARI Alessandro;
COLANERI Marta;
VECCHIA Marco;
SAMBO Margherita;
ZUCCARO Valentina;
ASPERGES Erika;
BRUNO Raffaele;
OGGIONNI Tiberio;
MELONI Federica;
ABOLHASSANI Hassan;
BERTOGLIO Federico;
SCHUBERT Maren;
CALZOLAI Luigi;
VARANI Luca;
HUST Michael;
XUE Yintong;
HAMMARSTRÖM Lennart;
BALDANTI Fausto;
PAN-HAMMARSTRÖM Qiang;
2023-07-31
CELL PRESS
JRC126784
2589-0042 (online),
https://www.sciencedirect.com/science/article/pii/S258900422200013X,
https://publications.jrc.ec.europa.eu/repository/handle/JRC126784,
10.1016/j.isci.2022.103743 (online),
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