Advanced Non-animal Models in Biomedical Research
Autoimmune diseases
The prevalence of autoimmune disorders is increasing worldwide. Whilst some treatments to manage symptoms do exist, there is a lack of effective options to stop and/or reverse the progression of the majority of these diseases. This is due in part to the fact that the causes and mechanisms of these conditions are difficult to identify as they include a mix of genetic, environmental and lifestyle factors, and that often they are studied in animal models which cannot fully replicate the complex biological interactions at play in these multifactorial diseases in humans.
Human-based alternative methods potentially represent more efficient options to elucidate disease mechanisms and discover potential drug targets. This study was conducted therefore, to systematically review non-animal models employed in the field of autoimmune disease research, and published in peer-reviewed journals between January 2014 and March 2019. It has produced a unique and highly curated knowledge base freely available to a variety of stakeholders in the research community and beyond.
OTERO Manel Juan;
CANALS Josep;
BELIO-MAIRAL Pedro;
NIC Miloslav;
DIBUSZ Krystof;
NOVOTNY Tomas;
BUSQUET Francois;
ROSSI Fabrizio;
GASTALDELLO Annalisa;
GRIBALDO Laura;
STRACCIA Marco;
DURA Adelaide;
WHELAN Maurice;
2022-11-24
Publications Office of the European Union
JRC131505
978-92-76-58966-2 (online),
978-92-76-58965-5 (print),
1831-9424 (online),
1018-5593 (print),
EUR 30334/6 EN,
OP KJ-NM-30-334-EN-N (online),
OP KJ-NM-30-334-EN-C (print),
https://publications.jrc.ec.europa.eu/repository/handle/JRC131505,
10.2760/617688 (online),
10.2760/604397 (print),
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