African Swine Fever (ASF) is a highly contagious and deathly disease that affects domestic and wild swine, representing a significant threat to the pork industry with economic consequences worldwide. Therefore, and since there are no available treatments, there is an urgent need for an ASF vaccine. To achieve that, several technical and regulatory challenges must be overcome.
Even though gaps in the knowledge of ASF virology and immunology are hindering the development of efficacious and safe vaccines, several vaccine candidates of different types have been proposed in recent years.
For a veterinary vaccine to be commercialized, a market authorisation application, comprising a comprehensive set of data concerning the quality, safety and efficacy of the candidate, has to be submitted to the competent authority. A major problem is that, so far, guidelines specific for ASF vaccine testing are not available.
This report addresses the global state of ASF vaccine progress, briefly overviewing the challenges that have been encountered, and the specific advantages and limitations of different types of vaccines. As well, it summarizes the applicability of the regulatory framework around the development of veterinary medicinal products to the case of ASF vaccines, and proposes a possible way forward towards the availability of safe ASF vaccines in the European Union based on setting up specific double-blind tests and minimum acceptance criteria for candidate vaccines.
COELHO CRUZ Bruna;
TOUSSAINT Brigitte;
MUNOZ PINEIRO Amalia;
MĖHN Dóra;
DENIN Nikolay;
RUIZ MORENO Ana;
VAN DEN EEDE Guy;
Coelho Cruz, B., Toussaint, B., Munoz Pineiro, A., Mėhn, D., Denin, N., Ruiz Moreno, A. and Van Den Eede, G., African Swine Fever (ASF) vaccine development: progress and challenges, Publications Office of the European Union, Luxembourg, 2023, doi:10.2760/209152, JRC134431.
2023-08-29
Publications Office of the European Union
JRC134431
978-92-68-08695-7 (online),
1831-9424 (online),
EUR 31718 EN,
OP KJ-NA-31-718-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC134431,
10.2760/209152 (online),
