ESAC Opinion No. 2025-01 of 24 January 2025
ESAC, the EURL ECVAM Scientific Advisory Committee, advises EURL ECVAM on scientific issues. Its main role is to conduct independent peer review of validation studies of alternative test methods and to assess their scientific validity for a given purpose. The committee reviews the appropriateness of study design and management, the quality of results obtained and the plausibility of the conclusions drawn. ESAC peer reviews are formally initiated with a EURL ECVAM Request for ESAC Advice, which provides the necessary background for the peer-review and establishes its objectives, timelines and the questions to be addressed. The peer review is normally prepared by specialised ESAC Sub-Groups. ESAC's advice to EURL ECVAM is formally provided as 'ESAC Opinions' and 'Sub-Group Reports' at the end of the peer review. ESAC may also issue Opinions on other scientific issues of relevance to the work and mission of EURL ECVAM but not directly related to a specific alternative test method.
The ESAC Opinion expressed in this report relates to the peer-review of the Reconstructed human Skin (RS) Comet and Micronucleus (RSMN) in vitro test methods for the assessment of genotoxicity.
CLEWELL Rebecca;
CORSINI Emanuela;
GRECO Dario;
KIENHUIS Anne;
LEHMANN David;
RODRÍGUEZ Blanca;
SEGNER Helmut;
TRALAU Tewes;
MENNECOZZI Milena;
CORVI Raffaella;
BARROSO João;
European Commission: Joint Research Centre, CLEWELL, R., CORSINI, E., GRECO, D., KIENHUIS, A., LEHMANN, D., RODRÍGUEZ, B., SEGNER, H. and TRALAU, T., ESAC Opinion on the Scientific Validity of the RS Comet and RSMN Test Methods, MENNECOZZI, M., CORVI, R. and BARROSO, J. editor(s), Publications Office of the European Union, Luxembourg, 2025, https://data.europa.eu/doi/10.2760/2520536, JRC140306.
2025-02-11
Publications Office of the European Union
JRC140306
978-92-68-22510-3 (online),
OP KJ-01-24-173-EN-N (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC140306,
10.2760/2520536 (online),
